2. Histamine Receptor Antagonism: Some sedatives, for example antihistamines, exert their sedative effects by blocking histamine receptors from the brain, notably H1 receptors. Histamine performs a task in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness. Don’t combine sedatives with each other or with other remedies https://cristianwuskz.boyblogguide.com/32145059/sedative-medications-in-icu-their-roles-effects